Study of novel dual topoisomerase poisons as potential anti-cancer drugs
XR5944 and XR11576 are two potent DNA interactive agents, previously shown to be capable of stabilising topoisomerase I and II cleavable complexes in vitro. This thesis investigated the possibility that the mechanism(s) of action of these compounds may be unrelated to that of topo inhibition. These...
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University of Surrey
2005
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418275 |