| Summary: | Calcium ions are an important second messenger in living cells. Indeed calcium signals in the form of waves have been the subject of much recent experimental interest. A fundamental approach for studying cellular signalling is the combination of state-of-the-art experimental techniques, in particular high-resolution fluorescence imaging, with spatio-temporal mathematical models of intracellular calcium regulation. Experimental findings can be incorporated into mathematical models and, vice versa, model predictions can be directly tested in experiments. This approach provides a powerful tool to clarify the very complex mechanisms involved in cellular Ca2+ signalling. The aim of this thesis is to provide insight into oscillations and waves of cytosolic Ca2+ in both single- and multi-cellular systems from a mathematical perspective.
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