The synthesis of morphine-6-glucuronide analogues as potential analgesics
It is known that morphine-6-glucuronide is more potent than morphine, but it is difficult and expensive to produce. Our aim was to synthesise an analogue(s) of morphine-6-glucuronide which would have similar or enhanced properties, but that could be obtained via a simple synthetic route. It is hoped...
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Loughborough University
1996
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ndltd-bl.uk-oai-ethos.bl.uk-3608622018-06-06T15:32:43ZThe synthesis of morphine-6-glucuronide analogues as potential analgesicsDi Pretoro, Anna M. A.1996It is known that morphine-6-glucuronide is more potent than morphine, but it is difficult and expensive to produce. Our aim was to synthesise an analogue(s) of morphine-6-glucuronide which would have similar or enhanced properties, but that could be obtained via a simple synthetic route. It is hoped that such a compound could be used to treat terminally ill cancer patients. Due to the enhanced potency a smaller dose of the drug would be required to effect the same analgesic effect as morphine, and this may help to reduce the effect of morphine tolerance.615.1Pharmacology & pharmacy & pharmaceutical chemistryLoughborough Universityhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360862https://dspace.lboro.ac.uk/2134/32407Electronic Thesis or Dissertation |
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NDLTD |
| sources |
NDLTD |
| topic |
615.1 Pharmacology & pharmacy & pharmaceutical chemistry |
| spellingShingle |
615.1 Pharmacology & pharmacy & pharmaceutical chemistry Di Pretoro, Anna M. A. The synthesis of morphine-6-glucuronide analogues as potential analgesics |
| description |
It is known that morphine-6-glucuronide is more potent than morphine, but it is difficult and expensive to produce. Our aim was to synthesise an analogue(s) of morphine-6-glucuronide which would have similar or enhanced properties, but that could be obtained via a simple synthetic route. It is hoped that such a compound could be used to treat terminally ill cancer patients. Due to the enhanced potency a smaller dose of the drug would be required to effect the same analgesic effect as morphine, and this may help to reduce the effect of morphine tolerance. |
| author |
Di Pretoro, Anna M. A. |
| author_facet |
Di Pretoro, Anna M. A. |
| author_sort |
Di Pretoro, Anna M. A. |
| title |
The synthesis of morphine-6-glucuronide analogues as potential analgesics |
| title_short |
The synthesis of morphine-6-glucuronide analogues as potential analgesics |
| title_full |
The synthesis of morphine-6-glucuronide analogues as potential analgesics |
| title_fullStr |
The synthesis of morphine-6-glucuronide analogues as potential analgesics |
| title_full_unstemmed |
The synthesis of morphine-6-glucuronide analogues as potential analgesics |
| title_sort |
synthesis of morphine-6-glucuronide analogues as potential analgesics |
| publisher |
Loughborough University |
| publishDate |
1996 |
| url |
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360862 |
| work_keys_str_mv |
AT dipretoroannama thesynthesisofmorphine6glucuronideanaloguesaspotentialanalgesics AT dipretoroannama synthesisofmorphine6glucuronideanaloguesaspotentialanalgesics |
| _version_ |
1718691951175270400 |