Structure-activity relationships of opioid ligands

Structure-activity relationships of opioid ligands

There are three different types of opioid receptor, namely mu, delta and kappa. Morphine and related clinically useful analgesics exert their actions through the mu opioid receptor. Such compounds represent a huge structural diversity, including both peptides and alkaloids. Nevertheless, there exist...

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Main Author: McFadyen, Iain James
Published: Loughborough University 1999
Subjects:
615.1
Pharmacology & pharmacy & pharmaceutical chemistry
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313444
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spelling ndltd-bl.uk-oai-ethos.bl.uk-3134442018-08-07T03:17:11ZStructure-activity relationships of opioid ligandsMcFadyen, Iain James1999There are three different types of opioid receptor, namely mu, delta and kappa. Morphine and related clinically useful analgesics exert their actions through the mu opioid receptor. Such compounds represent a huge structural diversity, including both peptides and alkaloids. Nevertheless, there exists a common pharmacophore comprising two critical features, namely an amine nitrogen and an aromatic ring, usually with a hydroxyl substituent; the spatial relationship between them is also vital.615.1Pharmacology & pharmacy & pharmaceutical chemistryLoughborough Universityhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313444https://dspace.lboro.ac.uk/2134/33189Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 615.1
Pharmacology & pharmacy & pharmaceutical chemistry
spellingShingle 615.1
Pharmacology & pharmacy & pharmaceutical chemistry
McFadyen, Iain James
Structure-activity relationships of opioid ligands
description There are three different types of opioid receptor, namely mu, delta and kappa. Morphine and related clinically useful analgesics exert their actions through the mu opioid receptor. Such compounds represent a huge structural diversity, including both peptides and alkaloids. Nevertheless, there exists a common pharmacophore comprising two critical features, namely an amine nitrogen and an aromatic ring, usually with a hydroxyl substituent; the spatial relationship between them is also vital.
author McFadyen, Iain James
author_facet McFadyen, Iain James
author_sort McFadyen, Iain James
title Structure-activity relationships of opioid ligands
title_short Structure-activity relationships of opioid ligands
title_full Structure-activity relationships of opioid ligands
title_fullStr Structure-activity relationships of opioid ligands
title_full_unstemmed Structure-activity relationships of opioid ligands
title_sort structure-activity relationships of opioid ligands
publisher Loughborough University
publishDate 1999
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313444
work_keys_str_mv AT mcfadyeniainjames structureactivityrelationshipsofopioidligands
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