Characterisation and use of radiotracers in studies of inflammatory tissue and opioid binding sites

Characterisation and use of radiotracers in studies of inflammatory tissue and opioid binding sites

The thesis is presented in two parts, part one concerns the synthesis and biodistribution of technetium–porphyrin complexes. A series of compounds with the general formula TcO(Porhyrin)OAc and TcO(Phthalocyanine)OPh have been synthesised via a novel route. The starting material comprised NH4TcO4 wit...

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Bibliographic Details
Main Author: Lawrence, Andrew John
Published: Loughborough University 1990
Subjects:
572
Technetium-porphyrin complexes
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253975
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spelling ndltd-bl.uk-oai-ethos.bl.uk-2539752018-06-06T15:32:43ZCharacterisation and use of radiotracers in studies of inflammatory tissue and opioid binding sitesLawrence, Andrew John1990The thesis is presented in two parts, part one concerns the synthesis and biodistribution of technetium–porphyrin complexes. A series of compounds with the general formula TcO(Porhyrin)OAc and TcO(Phthalocyanine)OPh have been synthesised via a novel route. The starting material comprised NH4TcO4 with acetic acid for the porphyrin and phenol for the phthalocyanine. The compounds have been characterised both qualitatively and quantitatively by infra-red, ultra-violet and mass spectrometry. Thin Layer Chromatography (TLC) and electrophoresis have also been employed to further analyse the complexes. Preliminary biodistribution studies have been performed in a model of inflamed tissue. The results suggest that the labelled porphyrins are capable of imaging such tissue. One of the complexes was tested for an ability to accumulate in, and image tumours, however this proved unsuccessful.572Technetium-porphyrin complexesLoughborough Universityhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253975https://dspace.lboro.ac.uk/2134/32936Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 572
Technetium-porphyrin complexes
spellingShingle 572
Technetium-porphyrin complexes
Lawrence, Andrew John
Characterisation and use of radiotracers in studies of inflammatory tissue and opioid binding sites
description The thesis is presented in two parts, part one concerns the synthesis and biodistribution of technetium–porphyrin complexes. A series of compounds with the general formula TcO(Porhyrin)OAc and TcO(Phthalocyanine)OPh have been synthesised via a novel route. The starting material comprised NH4TcO4 with acetic acid for the porphyrin and phenol for the phthalocyanine. The compounds have been characterised both qualitatively and quantitatively by infra-red, ultra-violet and mass spectrometry. Thin Layer Chromatography (TLC) and electrophoresis have also been employed to further analyse the complexes. Preliminary biodistribution studies have been performed in a model of inflamed tissue. The results suggest that the labelled porphyrins are capable of imaging such tissue. One of the complexes was tested for an ability to accumulate in, and image tumours, however this proved unsuccessful.
author Lawrence, Andrew John
author_facet Lawrence, Andrew John
author_sort Lawrence, Andrew John
title Characterisation and use of radiotracers in studies of inflammatory tissue and opioid binding sites
title_short Characterisation and use of radiotracers in studies of inflammatory tissue and opioid binding sites
title_full Characterisation and use of radiotracers in studies of inflammatory tissue and opioid binding sites
title_fullStr Characterisation and use of radiotracers in studies of inflammatory tissue and opioid binding sites
title_full_unstemmed Characterisation and use of radiotracers in studies of inflammatory tissue and opioid binding sites
title_sort characterisation and use of radiotracers in studies of inflammatory tissue and opioid binding sites
publisher Loughborough University
publishDate 1990
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253975
work_keys_str_mv AT lawrenceandrewjohn characterisationanduseofradiotracersinstudiesofinflammatorytissueandopioidbindingsites
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