Differential Roles of Mammalian Target of Rapamycin Complexes 1 and 2 in Migration of Prostate Cancer Cells

Differential Roles of Mammalian Target of Rapamycin Complexes 1 and 2 in Migration of Prostate Cancer Cells

In this study, we investigated differential activation and the role of two mTOR complexes in cell migration of prostate cancer cells. Specific knock-down of endogenous RAPTOR and RICTOR by siRNA resulted in decreased cell migration in LNCaP, DU145, and PC3 cells indicating that both mTORC1 and mTORC...

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Bibliographic Details
Main Author:	Venugopal, Smrruthi Vaidegi
Format:	Others
Published:	DigitalCommons@Robert W. Woodruff Library, Atlanta University Center 2019
Subjects:	Cell migration prostate cancer mTOR Rac1 PI3K/AKT pathway RICTOR Biology Cancer Biology Cell Biology Laboratory and Basic Science Research
Online Access:	http://digitalcommons.auctr.edu/cauetds/189 http://digitalcommons.auctr.edu/cgi/viewcontent.cgi?article=1341&context=cauetds

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