Developing a CRISPR-Mediated Knockout TCR Human T Cell Line for Use in Cloning Antigen-Specific T Cell Receptors

Developing a CRISPR-Mediated Knockout TCR Human T Cell Line for Use in Cloning Antigen-Specific T Cell Receptors

abstract: Adoptive transfer of T cells engineered to express synthetic antigen-specific T cell receptors (TCRs) has provocative therapeutic applications for treating cancer. However, expressing these synthetic TCRs in a CD4+ T cell line is a challenge. The CD4+ Jurkat T cell line expresses endogenou...

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Bibliographic Details
Other Authors: Hirneise, Gabrielle Rachel (Author)
Format: Dissertation
Language:English
Published: 2020
Subjects:
Biology
Cellular biology
Cancer
CRISPR
Immunology
Immunotherapies
T cell
T cell receptor
Online Access:http://hdl.handle.net/2286/R.I.57440

Internet

http://hdl.handle.net/2286/R.I.57440

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