Increasing T Cell Immunity to Metastatic Osteosarcoma via Modulation of Inhibitory T Cell Receptors

Increasing T Cell Immunity to Metastatic Osteosarcoma via Modulation of Inhibitory T Cell Receptors

abstract: Osteosarcoma is the most common bone cancer in children and adolescents. Patients with metastatic osteosarcoma are typically refractory to treatment. Numerous lines of evidence suggest that cytotoxic T-lymphocytes (CTL) limit the development of metastatic osteosarcoma. I have investigated...

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Bibliographic Details
Other Authors: Lussier, Danielle Marie (Author)
Format: Doctoral Thesis
Language:English
Published: 2015
Subjects:
Immunology
Molecular biology
Cellular biology
CTLA-4
Inhibitory Receptors
Metastatic Osteosarcoma
PD-1
PD-L1
T cell exhaustion
Online Access:http://hdl.handle.net/2286/R.I.29627

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