mGluR5 Positive Allosteric Modulation as a Novel Therapeutic Target for the Cognitive Deficits Associated with Schizophrenia
abstract: Patients with schizophrenia have impaired cognitive flexibility, as evidenced by behaviors of perseveration. Cognitive impairments may be due to dysregulation of glutamate and/or loss of neuronal plasticity in the medial prefrontal cortex (mPFC). The purpose of these studies was to examine...
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| Format: | Doctoral Thesis |
| Language: | English |
| Published: |
2014
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| Online Access: | http://hdl.handle.net/2286/R.I.25905 |