Protonation equilibria and pore-opening structure of the dual-histidine influenza B virus M2 transmembrane proton channel from solid-state NMR

The influenza A and B viruses are the primary cause of seasonal flu epidemics. Common to both viruses is the M2 protein, a homotetrameric transmembrane proton channel that acidifies the virion after endocytosis. Although influenza A M2 (AM2) and B M2 (BM2) are functional analogs, they have little se...

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Bibliographic Details
Main Authors: Williams, Jonathan K., Shcherbakov, Alexander A., Wang, Jun, Hong, Mei
Other Authors: Univ Arizona, Dept Pharmacol & Toxicol
Language:en
Published: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 2017
Online Access:http://hdl.handle.net/10150/626055
http://arizona.openrepository.com/arizona/handle/10150/626055