Pak2 regulates myeloid-derived suppressor cell development in mice

Pak2 regulates myeloid-derived suppressor cell development in mice

Myeloid-derived suppressor cells (MDSCs) are CD11b(+)Gr1(+) cells that induce T-cell hyporesponsiveness, thus impairing antitumor immunity. We have previously reported that disruption of Pak2, a member of the p21-activated kinases (Paks), in hematopoietic stem/progenitor cells (HSPCs) induces myeloi...

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Bibliographic Details
Main Authors:	Zeng, Yi, Hahn, Seongmin, Stokes, Jessica, Hoffman, Emely A., Schmelz, Monika, Proytcheva, Maria, Chernoff, Jonathan, Katsanis, Emmanuel
Other Authors:	Univ Arizona, Dept Pediat, Steele Childrens Res Ctr
Language:	en
Published:	AMER SOC HEMATOLOGY 2017
Online Access:	http://hdl.handle.net/10150/626038 http://arizona.openrepository.com/arizona/handle/10150/626038

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