Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol

Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol

Mitochondrial dysfunction is associated with numerous acute and chronic degenerative diseases. The beta-2 adrenergic receptor (beta(2)AR) agonist formoterol induces mitochondrial biogenesis (MB), but other beta(2)AR agonists, such as clenbuterol, do not. We sought to identify the MB signaling pathwa...

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Bibliographic Details
Main Authors:	Cameron, Robert B., Beeson, Craig C., Schnellmann, Rick G.
Other Authors:	Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol
Language:	en
Published:	NATURE PUBLISHING GROUP 2017
Online Access:	http://hdl.handle.net/10150/625746 http://arizona.openrepository.com/arizona/handle/10150/625746

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