Disulfide-Masked Prochelators Targeting the Iron Metabolism of Cancer: Design, Synthesis, and Biological Investigations
Iron is the most abundant transition metal found in living systems and plays a crucial role in DNA biosynthesis. To accommodate higher replication rates, cancer cells require higher amounts of iron compared to non-neoplastic counterparts. This higher demand for iron renders cancer cells susceptible...
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| Language: | en_US |
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The University of Arizona.
2016
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| Online Access: | http://hdl.handle.net/10150/623183 http://arizona.openrepository.com/arizona/handle/10150/623183 |