Relative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease
Nicotinamide delivered in drinking water at about 2 g/kg/day significantly prolonged survival and showed a suggestive improvement on memory in the Npc1 (nih) / Npc1 (nih) mouse model of infantile NPC1 disease. It is likely that this role is due to its function as a histone deacetylase (HDAC) inhibit...
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| Language: | en |
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SPRINGER HEIDELBERG
2016
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| Online Access: | http://hdl.handle.net/10150/622828 http://arizona.openrepository.com/arizona/handle/10150/622828 |