Relative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease

Relative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease

Nicotinamide delivered in drinking water at about 2 g/kg/day significantly prolonged survival and showed a suggestive improvement on memory in the Npc1 (nih) / Npc1 (nih) mouse model of infantile NPC1 disease. It is likely that this role is due to its function as a histone deacetylase (HDAC) inhibit...

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Bibliographic Details
Main Authors: Marshall, Craig A., Borbon, Ivan A., Erickson, Robert P.
Other Authors: Department of Pediatrics, University of Arizona
Language:en
Published: SPRINGER HEIDELBERG 2016
Subjects:
Histone deacetylase
Nicotinamide
Niemann-Pick C1 disease
Oxidative stress
Sirtuin
Valproic acid
Online Access:http://hdl.handle.net/10150/622828
http://arizona.openrepository.com/arizona/handle/10150/622828

Internet

http://hdl.handle.net/10150/622828
http://arizona.openrepository.com/arizona/handle/10150/622828

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