Epidermal mechano-acoustic sensing electronics for cardiovascular diagnostics and human-machine interfaces

Physiological mechano-acoustic signals, often with frequencies and intensities that are beyond those associated with the audible range, provide information of great clinical utility. Stethoscopes and digital accelerometers in conventional packages can capture some relevant data, but neither is suita...

Full description

Bibliographic Details
Main Authors: Liu, Y., Norton, J. J. S., Qazi, R., Zou, Z., Ammann, K. R., Liu, H., Yan, L., Tran, P. L., Jang, K.-I., Lee, J. W., Zhang, D., Kilian, K. A., Jung, S. H., Bretl, T., Xiao, J., Slepian, M. J., Huang, Y., Jeong, J.-W., Rogers, J. A.
Other Authors: Univ Arizona, Dept Med, Sarver Heart Ctr
Language:en
Published: AMER ASSOC ADVANCEMENT SCIENCE 2016
Online Access:http://hdl.handle.net/10150/622720
http://arizona.openrepository.com/arizona/handle/10150/622720
id ndltd-arizona.edu-oai-arizona.openrepository.com-10150-622720
record_format oai_dc
spelling ndltd-arizona.edu-oai-arizona.openrepository.com-10150-6227202017-03-04T03:00:46Z Epidermal mechano-acoustic sensing electronics for cardiovascular diagnostics and human-machine interfaces Liu, Y. Norton, J. J. S. Qazi, R. Zou, Z. Ammann, K. R. Liu, H. Yan, L. Tran, P. L. Jang, K.-I. Lee, J. W. Zhang, D. Kilian, K. A. Jung, S. H. Bretl, T. Xiao, J. Slepian, M. J. Huang, Y. Jeong, J.-W. Rogers, J. A. Univ Arizona, Dept Med, Sarver Heart Ctr Physiological mechano-acoustic signals, often with frequencies and intensities that are beyond those associated with the audible range, provide information of great clinical utility. Stethoscopes and digital accelerometers in conventional packages can capture some relevant data, but neither is suitable for use in a continuous, wearable mode, and both have shortcomings associated with mechanical transduction of signals through the skin. We report a soft, conformal class of device configured specifically for mechano-acoustic recording from the skin, capable of being used on nearly any part of the body, in forms that maximize detectable signals and allow for multimodal operation, such as electrophysiological recording. Experimental and computational studies highlight the key roles of low effective modulus and low areal mass density for effective operation in this type of measurement mode on the skin. Demonstrations involving seismocardiography and heart murmur detection in a series of cardiac patients illustrate utility in advanced clinical diagnostics. Monitoring of pump thrombosis in ventricular assist devices provides an example in characterization of mechanical implants. Speech recognition and human-machine interfaces represent additional demonstrated applications. These and other possibilities suggest broad-ranging uses for soft, skin-integrated digital technologies that can capture human body acoustics. 2016-11-16 Article Epidermal mechano-acoustic sensing electronics for cardiovascular diagnostics and human-machine interfaces 2016, 2 (11):e1601185 Science Advances 2375-2548 10.1126/sciadv.1601185 http://hdl.handle.net/10150/622720 http://arizona.openrepository.com/arizona/handle/10150/622720 Science Advances en http://advances.sciencemag.org/cgi/doi/10.1126/sciadv.1601185 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license. AMER ASSOC ADVANCEMENT SCIENCE
collection NDLTD
language en
sources NDLTD
description Physiological mechano-acoustic signals, often with frequencies and intensities that are beyond those associated with the audible range, provide information of great clinical utility. Stethoscopes and digital accelerometers in conventional packages can capture some relevant data, but neither is suitable for use in a continuous, wearable mode, and both have shortcomings associated with mechanical transduction of signals through the skin. We report a soft, conformal class of device configured specifically for mechano-acoustic recording from the skin, capable of being used on nearly any part of the body, in forms that maximize detectable signals and allow for multimodal operation, such as electrophysiological recording. Experimental and computational studies highlight the key roles of low effective modulus and low areal mass density for effective operation in this type of measurement mode on the skin. Demonstrations involving seismocardiography and heart murmur detection in a series of cardiac patients illustrate utility in advanced clinical diagnostics. Monitoring of pump thrombosis in ventricular assist devices provides an example in characterization of mechanical implants. Speech recognition and human-machine interfaces represent additional demonstrated applications. These and other possibilities suggest broad-ranging uses for soft, skin-integrated digital technologies that can capture human body acoustics.
author2 Univ Arizona, Dept Med, Sarver Heart Ctr
author_facet Univ Arizona, Dept Med, Sarver Heart Ctr
Liu, Y.
Norton, J. J. S.
Qazi, R.
Zou, Z.
Ammann, K. R.
Liu, H.
Yan, L.
Tran, P. L.
Jang, K.-I.
Lee, J. W.
Zhang, D.
Kilian, K. A.
Jung, S. H.
Bretl, T.
Xiao, J.
Slepian, M. J.
Huang, Y.
Jeong, J.-W.
Rogers, J. A.
author Liu, Y.
Norton, J. J. S.
Qazi, R.
Zou, Z.
Ammann, K. R.
Liu, H.
Yan, L.
Tran, P. L.
Jang, K.-I.
Lee, J. W.
Zhang, D.
Kilian, K. A.
Jung, S. H.
Bretl, T.
Xiao, J.
Slepian, M. J.
Huang, Y.
Jeong, J.-W.
Rogers, J. A.
spellingShingle Liu, Y.
Norton, J. J. S.
Qazi, R.
Zou, Z.
Ammann, K. R.
Liu, H.
Yan, L.
Tran, P. L.
Jang, K.-I.
Lee, J. W.
Zhang, D.
Kilian, K. A.
Jung, S. H.
Bretl, T.
Xiao, J.
Slepian, M. J.
Huang, Y.
Jeong, J.-W.
Rogers, J. A.
Epidermal mechano-acoustic sensing electronics for cardiovascular diagnostics and human-machine interfaces
author_sort Liu, Y.
title Epidermal mechano-acoustic sensing electronics for cardiovascular diagnostics and human-machine interfaces
title_short Epidermal mechano-acoustic sensing electronics for cardiovascular diagnostics and human-machine interfaces
title_full Epidermal mechano-acoustic sensing electronics for cardiovascular diagnostics and human-machine interfaces
title_fullStr Epidermal mechano-acoustic sensing electronics for cardiovascular diagnostics and human-machine interfaces
title_full_unstemmed Epidermal mechano-acoustic sensing electronics for cardiovascular diagnostics and human-machine interfaces
title_sort epidermal mechano-acoustic sensing electronics for cardiovascular diagnostics and human-machine interfaces
publisher AMER ASSOC ADVANCEMENT SCIENCE
publishDate 2016
url http://hdl.handle.net/10150/622720
http://arizona.openrepository.com/arizona/handle/10150/622720
work_keys_str_mv AT liuy epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT nortonjjs epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT qazir epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT zouz epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT ammannkr epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT liuh epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT yanl epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT tranpl epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT jangki epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT leejw epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT zhangd epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT kilianka epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT jungsh epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT bretlt epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT xiaoj epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT slepianmj epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT huangy epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT jeongjw epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
AT rogersja epidermalmechanoacousticsensingelectronicsforcardiovasculardiagnosticsandhumanmachineinterfaces
_version_ 1718419327508545536