Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus

Chikungunya virus (CHIKV) is a re-emerging global pathogen with pandemic potential, which causes fever, rash and debilitating arthralgia. Older adults over 65 years are particularly susceptible to severe and chronic CHIKV disease (CHIKVD), accounting for >90% of all CHIKV-related deaths. There ar...

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Bibliographic Details
Main Authors: Uhrlaub, Jennifer L., Pulko, Vesna, DeFilippis, Victor R., Broeckel, Rebecca, Streblow, Daniel N., Coleman, Gary D., Park, Byung S., Lindo, John F., Vickers, Ivan, Anzinger, Joshua J., Nikolich-Žugich, Janko
Other Authors: Univ Arizona, Coll Med, Dept Immunobiol
Language:en
Published: PUBLIC LIBRARY SCIENCE 2016
Online Access:http://hdl.handle.net/10150/622415
http://arizona.openrepository.com/arizona/handle/10150/622415