Monosialoganglioside-Containing Nanoliposomes Restore Endothelial Function Impaired by AL Amyloidosis Light Chain Proteins.

Monosialoganglioside-Containing Nanoliposomes Restore Endothelial Function Impaired by AL Amyloidosis Light Chain Proteins.

Light chain amyloidosis (AL) is associated with high mortality, especially in patients with advanced cardiovascular involvement. It is caused by toxicity of misfolded light chain proteins (LC) in vascular, cardiac, and other tissues. There is no treatment to reverse LC tissue toxicity. We tested the...

Full description

Bibliographic Details
Main Authors: Franco, Daniel A, Truran, Seth, Weissig, Volkmar, Guzman-Villanueva, Diana, Karamanova, Nina, Senapati, Subhadip, Burciu, Camelia, Ramirez-Alvarado, Marina, Blancas-Mejia, Luis M, Lindsay, Stuart, Hari, Parameswaran, Migrino, Raymond Q
Other Authors: Univ Arizona, Coll Med
Language:en
Published: WILEY-BLACKWELL 2016
Subjects:
amyloid
endothelium
nanotechnology
oxidant stress
Online Access:http://hdl.handle.net/10150/621716
http://arizona.openrepository.com/arizona/handle/10150/621716
Description
Summary:Light chain amyloidosis (AL) is associated with high mortality, especially in patients with advanced cardiovascular involvement. It is caused by toxicity of misfolded light chain proteins (LC) in vascular, cardiac, and other tissues. There is no treatment to reverse LC tissue toxicity. We tested the hypothesis that nanoliposomes composed of monosialoganglioside, phosphatidylcholine, and cholesterol (GM1 ganglioside-containing nanoliposomes [NLGM1]) can protect against LC-induced human microvascular dysfunction and assess mechanisms behind the protective effect.

Similar Items