The aryl hydrocarbon receptor agonist benzo(a)pyrene reactivates LINE-1 in HepG2 cells through canonical TGF-beta 1 signaling: implications in hepatocellular carcinogenesis

The aryl hydrocarbon receptor agonist benzo(a)pyrene reactivates LINE-1 in HepG2 cells through canonical TGF-beta 1 signaling: implications in hepatocellular carcinogenesis

Long interspersed nuclear element-1 (L1) is a genetic element that mobilizes throughout the mammalian genome via retrotransposition and damages host DNA via mutational insertions, chromosomal rearrangements, and reprogramming of gene expression. The cellular mechanisms responsible for aberrant L1 ex...

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Bibliographic Details
Main Authors: Reyes-Reyes, Elsa M, Ramos, Irma N, Tavera-Garcia, Marco A, Ramos, Kenneth S
Other Authors: Univ Arizona, Div Pulm Allergy Crit Care & Sleep Med, Coll Med
Language:en
Published: E-CENTURY PUBLISHING CORP 2016
Subjects:
Long interspersed nuclear element-1
benzo(a)pyrene
AhR
TGF-beta 1
SMAD
Online Access:http://hdl.handle.net/10150/621353
http://arizona.openrepository.com/arizona/handle/10150/621353

Internet

http://hdl.handle.net/10150/621353
http://arizona.openrepository.com/arizona/handle/10150/621353

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