Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

ABSTRACT: During inflammation, the kynurenine pathway (KP) metabolises the essential amino acid tryptophan (TRP) potentially contributing to excitotoxicity via the release of quinolinic acid (QUIN) and 3-hydroxykynurenine (3HK). Despite the importance of excitotoxicity in the development of secondar...

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Bibliographic Details
Main Authors: Yan, Edwin B., Frugier, Tony, Lim, Chai K., Heng, Benjamin, Sundaram, Gayathri, Tan, May, Rosenfeld, Jeffrey V., Walker, David W., Guillemin, Gilles J., Morganti-Kossmann, Maria C.
Other Authors: Department of Physiology, Monash University
Language:en
Published: BioMed Central 2015
Subjects:
Patients
Traumatic brain injury
Kynurenine pathway
Tryptophan metabolism
Quinolinic acid
Online Access:http://hdl.handle.net/10150/610324
http://arizona.openrepository.com/arizona/handle/10150/610324

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