Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor

Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor

BACKGROUND:Diffuse axonal injury is a common consequence of traumatic brain injury (TBI) and often co-occurs with hypoxia, resulting in poor neurological outcome for which there is no current therapy. Here, we investigate the ability of the multifunctional compound erythropoietin (EPO) to provide ne...

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Bibliographic Details
Main Authors: Hellewell, Sarah, Yan, Edwin, Alwis, Dasuni, Bye, Nicole, Morganti-Kossmann, M.
Other Authors: National Trauma Research Institute, Alfred Hospital, Level 4, Burnet Tower, 89 Commercial Road, Melbourne, VIC 3000, Australia
Language:en
Published: BioMed Central 2013
Subjects:
Traumatic brain injury (TBI)
Traumatic axonal injury
Hypoxia
Erythropoietin
EPO
Neuroprotection
Online Access:Hellewell et al. Journal of Neuroinflammation 2013, 10:156 http://www.jneuroinflammation.com/content/10/1/156
http://hdl.handle.net/10150/610192
http://arizona.openrepository.com/arizona/handle/10150/610192

Internet

Hellewell et al. Journal of Neuroinflammation 2013, 10:156 http://www.jneuroinflammation.com/content/10/1/156
http://hdl.handle.net/10150/610192
http://arizona.openrepository.com/arizona/handle/10150/610192

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