Heme oxygenase-1 induction in hepatocytes and non-parenchymal cells protects against liver injury during endotoxemia

Heme oxygenase-1 induction in hepatocytes and non-parenchymal cells protects against liver injury during endotoxemia

INTRODUCTION:Heme oxygenase-1 (HO-1) is a stress response enzyme, which catalyses the breakdown of heme into biliverdin-IX alpha, carbon monoxide and ferrous iron. Under situations of oxidative stress, heat stress, ischemia/reperfusion injury or endotoxemia, HO-1 has been shown to be induced and to...

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Bibliographic Details
Main Authors: Dorman, Robert, Bajt, Mary, Farhood, Anwar, Mayes, January, Jaeschke, Hartmut
Other Authors: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Language:en
Published: BioMed Central 2004
Online Access:Comparative Hepatology 2004, 3(Suppl 1):S42 http://www.comparative-hepatology.com/content/3/S1/S42
http://hdl.handle.net/10150/610124
http://arizona.openrepository.com/arizona/handle/10150/610124

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