Single amino acids in the carboxyl terminal domain of aquaporin-1 contribute to cGMP-dependent ion channel activation
BACKGROUND:Aquaporin-1 (AQP1) functions as an osmotic water channel and a gated cation channel. Activation of the AQP1 ion conductance by intracellular cGMP was hypothesized to involve the carboxyl (C-) terminus, based on amino acid sequence alignments with cyclic-nucleotide-gated channels and cGMP-...
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| Language: | en |
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BioMed Central
2003
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| Online Access: | BMC Physiology 2003, 3:12 http://www.biomedcentral.com/1472-6793/3/12 http://hdl.handle.net/10150/610075 http://arizona.openrepository.com/arizona/handle/10150/610075 |