The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration

The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration

BACKGROUND:Opioids are the cornerstone of treatment for moderate to severe pain, but chronic use leads to maladaptations that include: tolerance, dependence and opioid-induced hyperalgesia (OIH). These responses limit the utility of opioids, as well as our ability to control chronic pain. Despite de...

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Bibliographic Details
Main Authors: Liang, De-Yong, Zheng, Ming, Sun, Yuan, Sahbaie, Peyman, Low, Sarah, Peltz, Gary, Scherrer, Gregory, Flores, Cecilia, Clark, J.
Other Authors: Anesthesiology Service, Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, USA
Language:en
Published: BioMed Central 2014
Subjects:
Genetics
Mapping
Opioid
Pain
Addiction
Online Access:Liang et al. BMC Genomics 2014, 15:345 http://www.biomedcentral.com/1471-2164/15/345
http://hdl.handle.net/10150/610027
http://arizona.openrepository.com/arizona/handle/10150/610027

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