Effects of Lithium Treatment on Primary Cillia of Mouse Kidney
Treatment with lithium has been shown to have adverse effects on the kidney, but the mechanism has yet to be fully elucidated. In this study, kidney sections of four cohorts of mice were subjected to immunofluorescent labeling in order to determine the effects of lithium on primary cilia. It was fou...
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The University of Arizona.
2013
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| Online Access: | http://hdl.handle.net/10150/297774 |
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ndltd-arizona.edu-oai-arizona.openrepository.com-10150-297774 |
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ndltd-arizona.edu-oai-arizona.openrepository.com-10150-2977742014-02-05T15:20:01Z Effects of Lithium Treatment on Primary Cillia of Mouse Kidney Treister, Alison Diane McDermott, Kimberly Treatment with lithium has been shown to have adverse effects on the kidney, but the mechanism has yet to be fully elucidated. In this study, kidney sections of four cohorts of mice were subjected to immunofluorescent labeling in order to determine the effects of lithium on primary cilia. It was found that lithium had a lengthening effect on primary cilia in the inner medulla, outer medulla, and cortex regions of the kidney. It is thought that the effects of longer cilia may include a greater proportion of proteins in the primary cilia. This could lead to alterations in cell signaling in the kidney. Ultimately, lengthening of primary cilia may be responsible for modification of the principal cell and intercalated cell composition following lithium treatment. 2013-08-09T19:40:25Z 2013-08-09T19:40:25Z 2013 text Electronic Thesis http://hdl.handle.net/10150/297774 en Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. The University of Arizona. |
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NDLTD |
| language |
en |
| sources |
NDLTD |
| description |
Treatment with lithium has been shown to have adverse effects on the kidney, but the mechanism has yet to be fully elucidated. In this study, kidney sections of four cohorts of mice were subjected to immunofluorescent labeling in order to determine the effects of lithium on primary cilia. It was found that lithium had a lengthening effect on primary cilia in the inner medulla, outer medulla, and cortex regions of the kidney. It is thought that the effects of longer cilia may include a greater proportion of proteins in the primary cilia. This could lead to alterations in cell signaling in the kidney. Ultimately, lengthening of primary cilia may be responsible for modification of the principal cell and intercalated cell composition following lithium treatment. |
| author2 |
McDermott, Kimberly |
| author_facet |
McDermott, Kimberly Treister, Alison Diane |
| author |
Treister, Alison Diane |
| spellingShingle |
Treister, Alison Diane Effects of Lithium Treatment on Primary Cillia of Mouse Kidney |
| author_sort |
Treister, Alison Diane |
| title |
Effects of Lithium Treatment on Primary Cillia of Mouse Kidney |
| title_short |
Effects of Lithium Treatment on Primary Cillia of Mouse Kidney |
| title_full |
Effects of Lithium Treatment on Primary Cillia of Mouse Kidney |
| title_fullStr |
Effects of Lithium Treatment on Primary Cillia of Mouse Kidney |
| title_full_unstemmed |
Effects of Lithium Treatment on Primary Cillia of Mouse Kidney |
| title_sort |
effects of lithium treatment on primary cillia of mouse kidney |
| publisher |
The University of Arizona. |
| publishDate |
2013 |
| url |
http://hdl.handle.net/10150/297774 |
| work_keys_str_mv |
AT treisteralisondiane effectsoflithiumtreatmentonprimarycilliaofmousekidney |
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