COVALENTLY BOUND ORGANOHALOGEN METABOLITES TO LIPID COMPONENTS

Bioactivation of organohalogen xenobiotics produces reactive intermediates which alkylate macromolecules. The activation of carbon tetrachloride, trichloroethylene, and methylene chloride was studied in isolated rat hepatocytes by examining alkylation of lipid, protein, RNA, and DNA. All organohalog...

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Bibliographic Details
Main Author: Cunningham, Michael Lee
Other Authors: Sipes, I. Glenn
Language:en_US
Published: The University of Arizona. 1981
Subjects:
Online Access:http://hdl.handle.net/10150/281943