DESIGN, SYNTHESIS, AND CHARACTERIZATION OF HELICAL OPIOID GLYCOPEPTIDE AGONISTS: THE STUDY OF THE STRUCTURE-ACTIVITY RELATIONSHIP AND TRANSPORT OF GLYCOPEPTIDES RELATED TO BETA-ENDORPHIN AND DYNORPHIN
Structure-activity relationships (SAR) of opioid peptide analogues related to endorphin or dynorphin have provided rational and powerful approaches toward the design of peptide therapeutics. A series of glycosylated β-endorphin analogues were designed by modifying the N-terminal “message domain,” th...
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| Language: | en |
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The University of Arizona.
2011
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| Online Access: | http://hdl.handle.net/10150/203033 |