An Investigation of Solute Solubility in the Propellant HFA-134a
The reformulation of pressurized metered dose inhalers (MDIs) with hydrofluoroalkanes (HFAs) from chlorofluorocarbons (CFCs) has given rise to many solubility challenges. Compounds and excipients previously used in CFCs were observed to have significantly different solubility values in HFA-134a. In...
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| Language: | EN |
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The University of Arizona.
2007
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| Online Access: | http://hdl.handle.net/10150/196098 |