Drug Solubilization using N-Methyl Pyrrolidone: Efficiency and Mechanism

Drug Solubilization using N-Methyl Pyrrolidone: Efficiency and Mechanism

The solubilization efficiency of N-methyl pyrrolidone (NMP) has been determined and compared to that of ethanol and propylene glycol for 13 poorly soluble drugs. NMP is a more efficient solubilizer for all these drugs. The solubility enhancement as high as about 800-fold is obtained in 20% v/v NMP s...

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Bibliographic Details
Main Author:	Sanghvi, Ritesh
Other Authors:	Yalkowsky, Samuel H.
Language:	EN
Published:	The University of Arizona. 2006
Online Access:	http://hdl.handle.net/10150/194616

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