The effects of excipients on the structure and dynamics of insulin and the Lys(B28)Pro(B29) mutant: An NMR study.
The existence of multiple hexameric conformations of insulin has been well defined by x-ray crystallography. Insulin conformation within the hexamer has been shown to be dependent upon solution conditions, particularly, the presence of metal ions, protein concentration, pH and the presence of ligand...
| Main Author: | |
|---|---|
| Other Authors: | |
| Language: | en |
| Published: |
The University of Arizona.
1994
|
| Online Access: | http://hdl.handle.net/10150/187246 |