Synthetic approaches toward natural product synthesis.
1,2-Dithiolan-3-one-1-oxide exists in antihumor antibiotic leinamycin and can cause DNA cleavage in the presence of thiols. Diastereoselective synthesis of this unique ring system has been achieved by low temperature oxidation of the corresponding 1,2-dithiolan-3-ones with 3,3-dimethyldioxirane. 5-M...
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| Language: | en |
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The University of Arizona.
1995
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| Online Access: | http://hdl.handle.net/10150/187050 |