Directed Ortho-Metalation of the Three Methyl Anisoles in Various Media
Directed ortho-metalation (DoM) is a very useful alternative to electrophillic aromatic substitution (EAS) for the synthesis of substituted aromatic compounds. DoM is highly regiospecific providing metalation chiefly in the ortho-position. However, lateral (a-) metalation of an alkyl side-chain and...
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TopSCHOLAR®
1996
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Online Access: | http://digitalcommons.wku.edu/theses/870 http://digitalcommons.wku.edu/cgi/viewcontent.cgi?article=1873&context=theses |