Modeling of Cancer Signaling Pathways

Cancer is an ongoing problem all over the world. To find a cure to this disease, both clinicians and scientists are looking for a reasonable treatment method. According to Hanahan and Weinberg, one of the hallmarks of cancer is evasion of programmed cell death, referred to as apoptosis. Apoptosis is...

Full description

Bibliographic Details
Main Author: Karabekmez, Remziye
Language:en
Published: 2013
Subjects:
Online Access:http://hdl.handle.net/10012/7881
id ndltd-WATERLOO-oai-uwspace.uwaterloo.ca-10012-7881
record_format oai_dc
spelling ndltd-WATERLOO-oai-uwspace.uwaterloo.ca-10012-78812013-09-14T04:36:27ZKarabekmez, Remziye2013-09-13T19:54:51Z2013-09-13T19:54:51Z2013-09-13T19:54:51Z2013-09-04http://hdl.handle.net/10012/7881Cancer is an ongoing problem all over the world. To find a cure to this disease, both clinicians and scientists are looking for a reasonable treatment method. According to Hanahan and Weinberg, one of the hallmarks of cancer is evasion of programmed cell death, referred to as apoptosis. Apoptosis is an important cellular process, and is regulated by many different pathways. Proteins in these pathways contribute to either cell death or cell survival depending on the cell stresses. Much research in systems biology has been devoted to understanding these pathways at the molecular level. In this study a mathematical model is built to describe apoptosis, and the pathways involving the related proteins p53 and Akt. The primary purpose of the construction of the kinetic model is to verify that this network can exhibit bistability between cell survival and cell death. Sensitivity and bifurcation analysis are conducted to determine which parameters have the greatest effect on the system behavior.enApoptosisCell Signaling PathwaysBistabilityCancerModeling of Cancer Signaling PathwaysThesis or DissertationApplied MathematicsMaster of MathematicsApplied Mathematics
collection NDLTD
language en
sources NDLTD
topic Apoptosis
Cell Signaling Pathways
Bistability
Cancer
Applied Mathematics
spellingShingle Apoptosis
Cell Signaling Pathways
Bistability
Cancer
Applied Mathematics
Karabekmez, Remziye
Modeling of Cancer Signaling Pathways
description Cancer is an ongoing problem all over the world. To find a cure to this disease, both clinicians and scientists are looking for a reasonable treatment method. According to Hanahan and Weinberg, one of the hallmarks of cancer is evasion of programmed cell death, referred to as apoptosis. Apoptosis is an important cellular process, and is regulated by many different pathways. Proteins in these pathways contribute to either cell death or cell survival depending on the cell stresses. Much research in systems biology has been devoted to understanding these pathways at the molecular level. In this study a mathematical model is built to describe apoptosis, and the pathways involving the related proteins p53 and Akt. The primary purpose of the construction of the kinetic model is to verify that this network can exhibit bistability between cell survival and cell death. Sensitivity and bifurcation analysis are conducted to determine which parameters have the greatest effect on the system behavior.
author Karabekmez, Remziye
author_facet Karabekmez, Remziye
author_sort Karabekmez, Remziye
title Modeling of Cancer Signaling Pathways
title_short Modeling of Cancer Signaling Pathways
title_full Modeling of Cancer Signaling Pathways
title_fullStr Modeling of Cancer Signaling Pathways
title_full_unstemmed Modeling of Cancer Signaling Pathways
title_sort modeling of cancer signaling pathways
publishDate 2013
url http://hdl.handle.net/10012/7881
work_keys_str_mv AT karabekmezremziye modelingofcancersignalingpathways
_version_ 1716597666857615360