Enantioselective Conjugate Additions to Meldrum’s Acid Acceptors for the Synthesis of Quaternary Centres and Studies on Persistent Intramolecular C–H•••X (X = O, S, Br, Cl, and F) Hydrogen Bonds Involving Benzyl Meldrum’s Acids
The construction of benzylic quaternary stereocentres via the enantioselective copper-catalyzed 1,4-addition of dialkylzinc reagents to Meldrum’s acid acceptors in the presence of a phosphoramidite ligand is reported. Meldrum’s acid acceptors can be easily accessed and numerous derivatives have been...
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| Language: | en |
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2009
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| Online Access: | http://hdl.handle.net/10012/4650 |