Design and Modification of Half-Sandwich Ir(III), Rh(III), and Ru(II) Amino Acid Complexes for Application in Asymmetric Transfer Hydrogenation Reactions

Design and Modification of Half-Sandwich Ir(III), Rh(III), and Ru(II) Amino Acid Complexes for Application in Asymmetric Transfer Hydrogenation Reactions

This dissertation describes the design and synthesis of a series of half-sandwich amino acid complexes of the form), (aa = α-amino carboxylate), and their utility as asymmetric transfer hydrogenation catalysts of ketones. Variation of the metal center, the n-ring, and the aa was used to tune these s...

Full description

Bibliographic Details
Main Author: Morris, David
Other Authors: Chemistry
Format: Others
Published: Virginia Tech 2016
Subjects:
asymmetric transfer hydrogenation
amino acid
half-sandwich complex
iridium
rhodium
ruthenium
tetramethylcyclopentadiene
arene
solvent effects
Online Access:http://hdl.handle.net/10919/71819
id ndltd-VTETD-oai-vtechworks.lib.vt.edu-10919-71819
record_format oai_dc
spelling ndltd-VTETD-oai-vtechworks.lib.vt.edu-10919-718192020-09-29T05:35:11Z Design and Modification of Half-Sandwich Ir(III), Rh(III), and Ru(II) Amino Acid Complexes for Application in Asymmetric Transfer Hydrogenation Reactions Morris, David Chemistry Merola, Joseph S. Brewer, Karen J. Deck, Paul A. Hanson, Brian E. asymmetric transfer hydrogenation amino acid half-sandwich complex iridium rhodium ruthenium tetramethylcyclopentadiene arene solvent effects This dissertation describes the design and synthesis of a series of half-sandwich amino acid complexes of the form), (aa = α-amino carboxylate), and their utility as asymmetric transfer hydrogenation catalysts of ketones. Variation of the metal center, the n-ring, and the aa was used to tune these systems for specific sets of ketones. Upon reaction with homochiral]s, the ligand environment in all of these complexes is pseudotetrahedral, leading to stereogenic metal ions (SM, RM). The addition of another stereogenic center from the amino acid ligand (the carbon, RC or SC;glycine) gives rise to two pairs of diastereomeric complexes. Ph. D. 2016-07-22T06:00:12Z 2016-07-22T06:00:12Z 2015-01-28 Dissertation vt_gsexam:4391 http://hdl.handle.net/10919/71819 In Copyright http://rightsstatements.org/vocab/InC/1.0/ ETD application/pdf application/vnd.openxmlformats-officedocument.wordprocessingml.document Virginia Tech
collection NDLTD
format Others
sources NDLTD
topic asymmetric transfer hydrogenation
amino acid
half-sandwich complex
iridium
rhodium
ruthenium
tetramethylcyclopentadiene
arene
solvent effects
spellingShingle asymmetric transfer hydrogenation
amino acid
half-sandwich complex
iridium
rhodium
ruthenium
tetramethylcyclopentadiene
arene
solvent effects
Morris, David
Design and Modification of Half-Sandwich Ir(III), Rh(III), and Ru(II) Amino Acid Complexes for Application in Asymmetric Transfer Hydrogenation Reactions
description This dissertation describes the design and synthesis of a series of half-sandwich amino acid complexes of the form), (aa = α-amino carboxylate), and their utility as asymmetric transfer hydrogenation catalysts of ketones. Variation of the metal center, the n-ring, and the aa was used to tune these systems for specific sets of ketones. Upon reaction with homochiral]s, the ligand environment in all of these complexes is pseudotetrahedral, leading to stereogenic metal ions (SM, RM). The addition of another stereogenic center from the amino acid ligand (the carbon, RC or SC;glycine) gives rise to two pairs of diastereomeric complexes. === Ph. D.
author2 Chemistry
author_facet Chemistry
Morris, David
author Morris, David
author_sort Morris, David
title Design and Modification of Half-Sandwich Ir(III), Rh(III), and Ru(II) Amino Acid Complexes for Application in Asymmetric Transfer Hydrogenation Reactions
title_short Design and Modification of Half-Sandwich Ir(III), Rh(III), and Ru(II) Amino Acid Complexes for Application in Asymmetric Transfer Hydrogenation Reactions
title_full Design and Modification of Half-Sandwich Ir(III), Rh(III), and Ru(II) Amino Acid Complexes for Application in Asymmetric Transfer Hydrogenation Reactions
title_fullStr Design and Modification of Half-Sandwich Ir(III), Rh(III), and Ru(II) Amino Acid Complexes for Application in Asymmetric Transfer Hydrogenation Reactions
title_full_unstemmed Design and Modification of Half-Sandwich Ir(III), Rh(III), and Ru(II) Amino Acid Complexes for Application in Asymmetric Transfer Hydrogenation Reactions
title_sort design and modification of half-sandwich ir(iii), rh(iii), and ru(ii) amino acid complexes for application in asymmetric transfer hydrogenation reactions
publisher Virginia Tech
publishDate 2016
url http://hdl.handle.net/10919/71819
work_keys_str_mv AT morrisdavid designandmodificationofhalfsandwichiriiirhiiiandruiiaminoacidcomplexesforapplicationinasymmetrictransferhydrogenationreactions
_version_ 1719343828448575488

Similar Items