A Mathematical Model of a Denitrification Metabolic Network in Pseudomonas aeruginosa

• Main Author: Arat, Seda
• Other Authors: Mathematics
• Format: Others
• Published: Virginia Tech 2014
• Subjects: Discrete Models; Systems Biology; Dynamical Systems
• Online Access: http://hdl.handle.net/10919/46208; http://scholar.lib.vt.edu/theses/available/etd-12142012-115546/

Lake Erie, one of the Great Lakes in North America, has witnessed recurrent summertime low oxygen dead zones for decades. This is a yearly phenomenon that causes microbial production of the greenhouse gas nitrous oxide from denitrification. Complete denitrification is a microbial process of reduction of nitrate to nitrogen gas via nitrite, nitric oxide, and greenhouse gas nitrous oxide. After scanning the microbial community in Lake Erie, Pseudomonas aeruginosa is decided to be examined, not because it is abundant in Lake Erie, but because it can perform denitrification under anaerobic conditions. This study focuses on a mathematical model of the metabolic network in Pseudomonas aeruginosa under denitrification and testable hypotheses generation using polynomial dynamical systems and stochastic discrete dynamical systems. Analysis of the long-term behavior of the system changing the concentration level of oxygen, nitrate, and phosphate suggests that phosphate highly affects the denitrification performance of the network. === Master of Science