Factorial design for a sequential allocation study

• Main Author: Eckert, Robert Vernon
• Other Authors: Statistics
• Format: Others
• Language: en
• Published: Virginia Tech 2014
• Subjects: LD5655.V855 1961.E343; Drugs > Testing > Mathematical models; Factorial experiment designs
• Online Access: http://hdl.handle.net/10919/44046; http://scholar.lib.vt.edu/theses/available/etd-08012012-040115/

<p>Robert J. Taylor and Herbert A. David developed a new experimental approach in the screening of prospective drugs to be used in the treatment of cancer. The procedure is a sequential one, where the allocation of patients to drugs is based upon the performance of the drugs in immediately previous periods. Taylor further developed a computer program to study the effectiveness of the procedure by means of simulated trials.</p> <p> The purpose of this paper has been to study the sequential allocation procedure further by means of simulation in the form of a factorial experiment. Of primary concern has been the behavior of different weighting functions operating under varying experimental conditions. Response variables have been studied as a means for evaluating the effectiveness of the procedure. The results of this experiment are comparable with the findings originally presented by Taylor and David.</p> === Master of Science