Factorial design for a sequential allocation study
<p>Robert J. Taylor and Herbert A. David developed a new experimental approach in the screening of prospective drugs to be used in the treatment of cancer. The procedure is a sequential one, where the allocation of patients to drugs is based upon the performance of the drugs in immediately...
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| Format: | Others |
| Language: | en |
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Virginia Tech
2014
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| Online Access: | http://hdl.handle.net/10919/44046 http://scholar.lib.vt.edu/theses/available/etd-08012012-040115/ |
| Summary: | <p>Robert J. Taylor and Herbert A. David developed a new
experimental approach in the screening of prospective drugs
to be used in the treatment of cancer. The procedure is a
sequential one, where the allocation of patients to drugs is
based upon the performance of the drugs in immediately
previous periods. Taylor further developed a computer program
to study the effectiveness of the procedure by means of
simulated trials.</p>
<p>
The purpose of this paper has been to study the sequential
allocation procedure further by means of simulation in
the form of a factorial experiment. Of primary concern has
been the behavior of different weighting functions operating
under varying experimental conditions. Response variables
have been studied as a means for evaluating the effectiveness
of the procedure. The results of this experiment are
comparable with the findings originally presented by Taylor and David.</p> === Master of Science |
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