Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism
An important role of Pin1 is to catalyze the cis-trans isomerization of pSer/Thr-Pro bonds; as such, it plays an important role in many cellular events through the effects of conformational change on the function of its biological substrates, including Cdc25, c-Jun, and p53. The expression of Pin1 c...
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Virginia Tech
2014
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| Online Access: | http://hdl.handle.net/10919/37823 http://scholar.lib.vt.edu/theses/available/etd-05182010-223754/ |