Synthesis of Taxol™ Analogs as Conformational Probes
Taxol™, isolated from the bark of Taxus brevifolia in the late 1960s, and the semisynthetic analog Taxotere™ have proven clinical importance for the treatment of ovarian and breast cancer. Taxol™ exerts its biological effect by binding to polymerized tubulin and stabilizing the resulting microtubul...
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Virginia Tech
2014
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| Online Access: | http://hdl.handle.net/10919/28428 http://scholar.lib.vt.edu/theses/available/etd-07282002-181151/ |