Synthesis and Optimization of a Model System Representing the Natural Product Marineosin A and Discovery of VU0431316, a Negative Allosteric Modulator of the Metabotropic Glutamate Receptor 5
Marineosin A was isolated from a marine sediment-derived actinomycete in 2008. The intriguing biological activity and novel chemical structure warranted completion of the total synthesis of this compound. The model systems described herein were created as tools to develop chemistry and test the viab...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2013
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-12112013-231032/ |