Reduced Striatal Mn-accumulation in Huntingtonâs Disease Mouse Model Causes Reversible Alterations in Mn-dependent Enzyme Pathways
Huntingtonâs disease (HD) is caused by an increase in CAG repeats in exon 1 of the huntingtin gene (HTT), which results in a polyglutamine expansion in the HTT protein. This mutation causes profound striatal neurodegeneration through an unknown mechanism, which adversely affects multiple cellular pr...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2016
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-12052016-221132/ |