EFFECT OF MAPK INHIBITION ON CELL CYCLE REGULATION OF THYMIDINE KINASE 1 AND [18F]-FLT PET

Positron emission tomography (PET) imaging using the radiotracer 3-deoxy-3-[18F]fluorothymidine ([18F]-FLT) has shown potential as a biomarker of proliferation in tumors. [18F]-FLT measures the activity of thymidine kinase 1 (TK1), which is related to cell proliferation. The relationship between [18...

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Bibliographic Details
Main Author: Mutic, Nathan James
Other Authors: John C. Gore
Format: Others
Language:en
Published: VANDERBILT 2009
Subjects:
Online Access:http://etd.library.vanderbilt.edu//available/etd-12032009-212556/