Tissue-specific regulation and function of Pancreatic and duodenal homeobox 1
The transcription factor Pancreatic and duodenal homeobox 1 (Pdx1) is essential for formation of the pancreas and for glucose-responsive insulin secretion from mature pancreatic beta cells. In humans and mice, heterozygosity for inactivating mutations in the Pdx1 gene confers a high risk of early-on...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2006
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-11302006-002218/ |