PROARRHYTHMIC DEFECTS IN TIMOTHY SYNDROME REQUIRE CALMODULIN KINASE II

PROARRHYTHMIC DEFECTS IN TIMOTHY SYNDROME REQUIRE CALMODULIN KINASE II

Ca2+ activated signaling pathways coordinate contraction in the heart, but these pathways cause disease upon excessive activation. Intracellular Ca2+ activates the multifunctional Ca2+ and calmodulin dependent protein kinase II (CaMKII) and activated CaMKII increases Ca2+ entry, by a feed-forward pr...

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Bibliographic Details
Main Author:	Thiel, William Howard
Other Authors:	Brian Wadzinski
Format:	Others
Language:	en
Published:	VANDERBILT 2008
Subjects:	Pharmacology
Online Access:	http://etd.library.vanderbilt.edu/available/etd-11172008-100413/

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