PROARRHYTHMIC DEFECTS IN TIMOTHY SYNDROME REQUIRE CALMODULIN KINASE II
Ca2+ activated signaling pathways coordinate contraction in the heart, but these pathways cause disease upon excessive activation. Intracellular Ca2+ activates the multifunctional Ca2+ and calmodulin dependent protein kinase II (CaMKII) and activated CaMKII increases Ca2+ entry, by a feed-forward pr...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2008
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-11172008-100413/ |