Synthesis and in vitro replicatuion studies of N5-alkylated formamidopyrimicine (FAPy-dGuo) adducts in DNA.
Methylating agents react with DNA to give the cationic N7-methyl deoxyguanosine adduct, which can undergo hydrolytic opening of the imidazole ring to form 2,6-diamino-4-hydroxy-N5-(methyl)-formamido-pyrimidine (MeFAPy-dGuo) adduct. MeFAPy-dGuo lesion represents an important but largely unexplored cl...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2007
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-10082007-083404/ |