Characterization of synthetic lethality between Mdm2 overexpression and genotoxic agents and identification of a novel function of the Mdmx oncogene in DNA repair
The oncogenes Mdm2 and Mdmx are often overexpressed in many human cancers. In addition to being negative regulators of the tumor suppressor p53, there is evidence these proteins have important p53-independent functions that are not clearly understood. Recently, a novel function of Mdm2 was identifie...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2014
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-08142014-151931/ |