REGULATION OF PP2Ac STABILITY DISCOVERY OF A NOVEL α4 MONOUBIQUITINATION-DEPENDENT MECHANISM THAT IS ALTERED IN ALZHEIMERS DISEASE

REGULATION OF PP2Ac STABILITY DISCOVERY OF A NOVEL α4 MONOUBIQUITINATION-DEPENDENT MECHANISM THAT IS ALTERED IN ALZHEIMERS DISEASE

Studies described in this thesis identify a novel mechanism for α4s regulation of PP2Ac stability. α4 binds the PP2A catalytic subunit (PP2Ac) and the microtubule-associated E3 ubiquitin ligase MID1, and through unknown mechanisms can both reduce and enhance PP2Ac stability. We show MID1-dependent m...

Full description

Bibliographic Details
Main Author:	Watkins, Guy Richard
Other Authors:	vsevolod Gurevich
Format:	Others
Language:	en
Published:	VANDERBILT 2012
Subjects:	Pharmacology
Online Access:	http://etd.library.vanderbilt.edu/available/etd-08062012-134256/

Similar Items

Development of a Novel Pharmacological Model of Okadaic Acid-induced Alzheimer’s Disease in Zebrafish and its use in Drug Discovery
by: Koehler, Daniel
Published: (2018)

Drug Discovery
Published: (2013)

Dynamic Regulation and Function of Histone Monoubiquitination in Plants
by: Jing eFeng, et al.
Published: (2014-03-01)

Drug Discovery Research in Pharmacognosy
Published: (2012)

Drug Discovery
Published: (2013)

Regulation of the CaMKIV/PP2A Signaling Module
by: Reece, Kelie M'liss
Published: (2010)

Drug Discovery and Development New Advances
Published: (2020)

Drug Discovery and Development Present and Future
Published: (2011)

Discovery of a novel lipoxygenase pathway in skin
by: Yu, Zheyong
Published: (2005)

High-Throughput Screening for Drug Discovery
Published: (2022)

Characterization of Rpn10 monoubiquitination as a novel way of proteasome regulation
by: Isasa Catalán, Marta
Published: (2012)

Posttranslational regulation of protein function and stability at the mitochondria and beyond
by: Nifoussi, Shanna Katherine
Published: (2010)

Mediator kinase submodule-dependent regulation of cardiac transcription
by: Minerath, Rachel Ann
Published: (2019)

Cracking the Monoubiquitin Code of Genetic Diseases
by: Raj Nayan Sewduth, et al.
Published: (2020-04-01)

Mechanisms of monoubiquitination in the Fanconi anemia pathway
by: Miles, J. A.
Published: (2014)

The role of Alpha4 in regulating the PP2A family of serine/threonine phosphatases: a structural, biochemical and cell-based approach
by: LeNoue-Newton, Michele Laura
Published: (2015)

The role and regulation of histone H2B monoubiquitination during tumorigenesis
by: Gorsler, Theresa
Published: (2014)

CRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection
by: Ming Zeng, et al.
Published: (2016-04-01)

Systems Pharmacology in Small Molecular Drug Discovery
by: Wei Zhou, et al.
Published: (2016-02-01)

Differentially Functionalized Silver Nanoparticles Alter K Metabolism in Human Red Blood Cells
by: Alla, Praveen Kumar
Published: (2016)

Discovery, Optimization, and Characterization of Novel Subtype-Selective Muscarinic Acetylcholine Receptor M4 and M5 Positive Allosteric Modulators
by: Bridges, Thomas Miller
Published: (2010)

An investigation of privileged substructural motifs as templates for the discovery and design of chloroquine-resistance reversal agents
by: Yeh, Susan
Published: (2014)

CA2+-SELECTIVE TRPM CHANNELS REGULATE IP3-DEPENDENT CA2+ OSCILLATIONS IN THE C. ELEGANS INTESTINE
by: Xing, Juan
Published: (2009)

Investigating the Modulation and Mechanisms of α7 Nicotinic Acetylcholine Receptors in Nicotine Dependence
by: Jackson, Asti
Published: (2017)

THE ROLE OF CA2+/CALMODULIN-DEPENDENT KINASE II IN NORMAL AND ABNORMAL EARLY POSTNATAL DEVELOPMENT
by: Gustin, Richard Michael
Published: (2010)

Discovery and characterization of allosteric CD45 inhibitors
by: Perron, Michael
Published: (2013)

Discovery And Validation Of Early Life Plasma Protein Biomarkers For Childhood Asthma
by: Xu, Haili
Published: (2014)

Biased allosteric regulation of the Prostaglandin F2α receptor: from small molecules to large receptor complexes
by: Goupil, Eugénie
Published: (2013)

The role of H2B monoubiquitination in cellular differentiation
by: Karpiuk, Oleksandra
Published: (2013)

Function of histone H2B monoubiquitination in transcriptional regulation of auxin biosynthesis in Arabidopsis
by: Li Zhang, et al.
Published: (2021-02-01)

Tau-Directed Immunotherapy for Alzheimer's Disease
by: Schroeder, Sulana K.
Published: (2017)

Cortical participation in learning and memory tasks in a novel Alzheimer's disease transgenic rat model
by: León, Wanda
Published: (2011)

Oxidative stress in C. elegans: Discovery of a mechanistic role for gamma-ketoaldehyde lipid peroxidation products in the Free Radical Theory of Aging
by: Nguyen, Thuy Tuong
Published: (2016)

Delivery of Vaccinia Virus Complement Control Protein (VCP) and Curcumin to the rodents' brain : implications in Alzheimer's disease and HIV dementia
by: Kulkarni, Amod Prakash
Published: (2014)

SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway
by: Irene Santos-Barriopedro, et al.
Published: (2018-01-01)

Function of RNF20-dependent H2B monoubiquitination in DNA double strand break repair
by: Nakamura, Kyosuke
Published: (2011)

Discovery and Characterization of Selective Negative Allosteric Modulators of Human α4β2 Neuronal Nicotinic Receptors
by: Henderson, Brandon J.
Published: (2011)

Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
by: Haithem Barbour, et al.
Published: (2020-11-01)

Studies on early CNS inflammation in transgenic models of the Alzheimer's pathology
by: Sa Barreto Pimentel, Luisa
Published: (2014)

Cardiovascular Responses in Normal and High Fat-Cholesterol Fed Rabbits with Special Reference to Altered Thyroid States.
by: Martel, Rene.
Published: (1960)