REGULATION OF PP2Ac STABILITY DISCOVERY OF A NOVEL α4 MONOUBIQUITINATION-DEPENDENT MECHANISM THAT IS ALTERED IN ALZHEIMERS DISEASE
Studies described in this thesis identify a novel mechanism for α4s regulation of PP2Ac stability. α4 binds the PP2A catalytic subunit (PP2Ac) and the microtubule-associated E3 ubiquitin ligase MID1, and through unknown mechanisms can both reduce and enhance PP2Ac stability. We show MID1-dependent m...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2012
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-08062012-134256/ |